Page last updated: 2024-08-18

pyrroles and 6-[(3-aminophenyl)methyl]-4-methyl-2-methylsulfinyl-5-thieno[3,4]pyrrolo[1,3-d]pyridazinone

pyrroles has been researched along with 6-[(3-aminophenyl)methyl]-4-methyl-2-methylsulfinyl-5-thieno[3,4]pyrrolo[1,3-d]pyridazinone in 14 studies

Research

Studies (14)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	14 (100.00)	2.80

Authors

Authors	Studies
Angiari, S; Kane, H; Kelly, B; Mills, KHG; O'Neill, LAJ; Palsson-McDermott, EM; Papadopoulou, G; Pearce, EL; Rana, N; Runtsch, MC; Sutton, CE	1
Besirli, CG; Dai, L; Hager, H; Lyssiotis, CA; Pai, MP; Pawar, M; Sajjakulnukit, P; Smith, A; Weh, E; Wubben, TJ; Zhang, L	1
Jiang, S	1
Chen, H; Chen, P; Cheng, G; Fan, J; He, L; Hong, J; Hu, K; Jiang, Y; Li, J; Lin, L; Lin, W; Lin, Z; Qu, C; Tu, M; Yuan, H; Zheng, D	1
Finlay, DK; Gardiner, CM; Gonzalez-Cotto, M; McVicar, DW; Palmieri, EM; Subleski, JJ; Walls, JF	1
Beiter, RM; Bullock, TNJ; Fernández-Castañeda, A; Gaultier, A; Gemta, L; Hayes, N; Hsu, KL; McCloud, R; Nanziri, SC; Posyniak, K; Rosen, DA; Seki, SM; Serbulea, V; Spivey, C	1
Kanasaki, K; Koya, D; Kumagai, A; Liu, H; Takagaki, Y	1
Lai, X; Wu, H; Yang, SH; Yi, ZJ	1
Apostolidi, M; Gassaway, BM; Gaule, P; Muthusamy, V; Rimm, DL; Rinehart, J; Vathiotis, IA	1
Benvie, A; Berry, D; Blum, JE; Field, MS; Gheller, BJ; Panizza, E; Thalacker-Mercer, A; Vacanti, NM	1
Hu, K; Huang, J; Jiang, R; Li, L; Lin, L; Lv, X; Shen, Y; Tang, L; Wan, J; Yang, Y; Zhang, L; Zhou, H	1
Li, H; Liu, Z; Shu, J; Su, G; Xu, J; Yang, P; Zhou, C	1
Allen, CNS; Arjona, SP; Ghaleb, LJ; Herzi, M; Llewellyn, MD; Santerre, M; Sawaya, BE; Shcherbik, N	1
Hao, D; Liu, X; Wang, X; Wang, Z; Yu, J	1

Reviews

1 review(s) available for pyrroles and 6-[(3-aminophenyl)methyl]-4-methyl-2-methylsulfinyl-5-thieno[3,4]pyrrolo[1,3-d]pyridazinone

Article	Year
Tetrameric PKM2 Activation Curbs CD4 Trends in endocrinology and metabolism: TEM, 2020, Volume: 31, Issue:6 Topics: Animals; CD4-Positive T-Lymphocytes; Encephalomyelitis, Autoimmune, Experimental; Humans; Pyridazines; Pyrroles; Pyruvate Kinase; Th1 Cells; Th17 Cells	2020

Other Studies

13 other study(ies) available for pyrroles and 6-[(3-aminophenyl)methyl]-4-methyl-2-methylsulfinyl-5-thieno[3,4]pyrrolo[1,3-d]pyridazinone

Article	Year
Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4 Cell metabolism, 2020, 02-04, Volume: 31, Issue:2 Topics: Animals; Autoimmunity; Carrier Proteins; Cells, Cultured; Enzyme Activators; Female; Humans; Inflammation; Membrane Proteins; Mice; Mice, Inbred C57BL; Pyridazines; Pyrroles; Th1 Cells; Thyroid Hormone-Binding Proteins; Thyroid Hormones	2020
Small molecule activation of metabolic enzyme pyruvate kinase muscle isozyme 2, PKM2, circumvents photoreceptor apoptosis. Scientific reports, 2020, 02-19, Volume: 10, Issue:1 Topics: Animals; Apoptosis; Blindness; Cell Line; Disease Models, Animal; Enzyme Activators; Glycolysis; Humans; Intravitreal Injections; Male; Mice; Mice, Knockout; Photoreceptor Cells; Protein Isoforms; Pyridazines; Pyrroles; Pyruvate Kinase; Rabbits; Rats; Retinal Diseases	2020
Pyruvate Kinase M2 Tetramerization Protects against Hepatic Stellate Cell Activation and Liver Fibrosis. The American journal of pathology, 2020, Volume: 190, Issue:11 Topics: Acetylation; Animals; Cyclin D1; Female; Hepatic Stellate Cells; Histones; Humans; Liver Cirrhosis; Male; Mice; Organic Chemicals; Protein Multimerization; Proto-Oncogene Proteins c-myc; Pyridazines; Pyrroles; Pyruvate Kinase	2020
Metabolic but not transcriptional regulation by PKM2 is important for natural killer cell responses. eLife, 2020, 08-19, Volume: 9 Topics: Animals; Cells, Cultured; Gene Expression Regulation; Glycolysis; Killer Cells, Natural; Mice; Oxidative Stress; Pyridazines; Pyrroles; Pyruvate Kinase; Signal Transduction	2020
Modulation of PKM activity affects the differentiation of T Science signaling, 2020, 10-27, Volume: 13, Issue:655 Topics: Animals; Cell Differentiation; Female; Male; Mice; Mice, Knockout; Multiple Sclerosis; Pyridazines; Pyrroles; Pyruvate Kinase; Signal Transduction; Th17 Cells; Transforming Growth Factor beta1	2020
The PKM2 activator TEPP-46 suppresses kidney fibrosis via inhibition of the EMT program and aberrant glycolysis associated with suppression of HIF-1α accumulation. Journal of diabetes investigation, 2021, Volume: 12, Issue:5 Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Epithelial-Mesenchymal Transition; Fibrosis; Glycolysis; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney; Mice; Oxidative Phosphorylation; Pyridazines; Pyrroles; Pyruvate Kinase; Streptozocin	2021
The PKM2 activator TEPP-46 attenuates MCD feeding-induced nonalcoholic steatohepatitis by inhibiting the activation of Kupffer cells. European review for medical and pharmacological sciences, 2021, Volume: 25, Issue:11 Topics: Animals; Choline; Cytokines; Diet; Inflammasomes; Kupffer Cells; Liver; Male; Methionine; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Non-alcoholic Fatty Liver Disease; Pyridazines; Pyrroles; Pyruvate Kinase	2021
Targeting Pyruvate Kinase M2 Phosphorylation Reverses Aggressive Cancer Phenotypes. Cancer research, 2021, 08-15, Volume: 81, Issue:16 Topics: Active Transport, Cell Nucleus; Animals; Biomarkers, Tumor; Carrier Proteins; Cell Line, Tumor; Collagen; Cyclic N-Oxides; Drug Combinations; Genome, Human; Humans; Indolizines; Laminin; MCF-7 Cells; Membrane Proteins; Mice; Neoplasm Invasiveness; Neoplasm Transplantation; Neoplasms; Oxidation-Reduction; Phenotype; Phosphorylation; Protein Isoforms; Proteoglycans; Proteomics; Pyridazines; Pyridinium Compounds; Pyrroles; Pyruvate Kinase; Thyroid Hormone-Binding Proteins; Thyroid Hormones; Triple Negative Breast Neoplasms	2021
Pyruvate Kinase M2 Supports Muscle Progenitor Cell Proliferation but Is Dispensable for Skeletal Muscle Regeneration after Injury. The Journal of nutrition, 2021, 11-02, Volume: 151, Issue:11 Topics: Animals; Cell Proliferation; Glycolysis; Mice; Muscle Fibers, Skeletal; Pyridazines; Pyrroles; Pyruvate Kinase; Regeneration	2021
Activation of PKM2 metabolically controls fulminant liver injury via restoration of pyruvate and reactivation of CDK1. Pharmacological research, 2021, Volume: 172 Topics: Animals; Apoptosis; CDC2 Protein Kinase; Galactosamine; Hepatocytes; Lipopolysaccharides; Liver; Liver Diseases; Male; Mice; Mice, Inbred BALB C; Pyridazines; Pyrroles; Pyruvate Kinase; Pyruvates; Pyruvic Acid	2021
PD-1 Targeted Nanoparticles Inhibit Activated T Cells and Alleviate Autoimmunity via Suppression of Cellular Energy Metabolism Mediated by PKM2. International journal of nanomedicine, 2022, Volume: 17 Topics: Animals; Autoimmune Diseases; Autoimmunity; Disease Models, Animal; Energy Metabolism; Mice; Mice, Inbred C57BL; Nanoparticles; Programmed Cell Death 1 Receptor; Pyridazines; Pyrroles; Pyruvate Kinase; Th1 Cells; Th17 Cells	2022
SARS-CoV-2 Causes Lung Inflammation through Metabolic Reprogramming and RAGE. Viruses, 2022, 05-06, Volume: 14, Issue:5 Topics: COVID-19; Humans; Inflammation; Pneumonia; Pyridazines; Pyrroles; SARS-CoV-2	2022
Transcriptomic signatures responding to PKM2 activator TEPP-46 in the hyperglycemic human renal proximal epithelial tubular cells. Frontiers in endocrinology, 2022, Volume: 13 Topics: Biomarkers; Diabetic Nephropathies; ErbB Receptors; Glucose; Humans; MicroRNAs; Pyridazines; Pyrroles; Pyruvate Kinase; Pyruvic Acid; Transcriptome; Tumor Suppressor Protein p53	2022